Yes, mixing color temperatures can create effective layered lighting when done intentionally. A common approach is using 3000K warm white for ambient and accent lighting (cove lights, spotlights) paired with 4000K neutral white for task lighting (desk lamps, under-cabinet lights). The key is to keep each lighting layer consistent within itself and avoid placing two different CCTs adjacent to each other where the difference becomes obvious. For example, don't mix 3000K and 5000K downlights in the same ceiling grid. Use tunable white fixtures if you need flexibility. In commercial spaces, mixing CCTs can help zone different functional areas, but always consult a lighting designer to avoid a disjointed appearance.